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Supplementary prognostic variables for pleural mesothelioma: a report from the IASLC staging committee

The ischemia and reperfusion may occur in the cardiac surgeries, where the re-oxigenation can cause serious arrhythmias with extense lesions due to the oxygen paradoxal shock, which causes ATP depletion during the ischemia, forming hypoxanthine or xanthine, that work like a substrate to the xanthine oxidase enzyme (XO), precursor form the uric acid, that acts like na antioxidant in these cases

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This means that while your body can usually produce enough of it on its own, there are timessuch as during periods of high physical stress, intense exercise, or recoverywhen your bodys demand for it may exceed its ability to produce it